ea0037ep728 | Pituitary: clinical | ECE2015
Efstathiadou Zoe A
, Bargiota Alexandra
, Chrisoulidou Alexandra
, Kanakis Georgios
, Papanastasiou Lamprini
, Theodoropoulou Anastasia
, Tigas Stylianos K
, Vassiliadi Dimitra
, Alevizaki Maria
, Tsagarakis Stylianos
Objective: Somatic mutations in the GNAS1 gene, which encodes the alpha-subunit of G stimulatory proteins (gsp), are frequently detected in somatotroph pituitary tumors and have been associated to specific clinical-smaller and less invasive tumors occurring in older patients- and histopathological-densely granulated adenomas- characteristics. However, the question whether the presence of a somatic gsp mutation affects the response to somatostatin analogue treatment remains unr...